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In T lymphocytes, the antigen T-cell receptor (TCR) is a multiple subunit complex comprising clonotypic, disulfide-linked α and β antigen recognition chains devoid of signaling motifs associated with the invariant chain subunits CD3γ, δ, and ϵ, and TCRζ.
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In contrast, the ovalbumin signal sequence is much more efficient, whereas the corresponding sequence elements from LEI, maspin and PI-10 are entirely devoid of signal sequence activity in E. coli.
Interestingly, ∼5 12% of cells per exposed male were devoid of signal, suggesting loss of Y chromosome.
Even TCTP devoid of signal sequences, is secreted to extracellular environment by an yet undefined mechanism.
An area of the gel image that was devoid of signal was assigned to be the background value.
In the analysis by Wang et al. [45], which is based on data largely overlapping with the previous work, NAT2 falls in a chromosomal region devoid of signals.
It is a noteworthy observation however that in the RARE-hsp68-lacZ transgenic mice, liver was devoid of signal indicating RA activity, in keeping with our HPLC results earlier on the absence of endogenous all-trans RA [7].
13 Controls with sense probes were devoid of signal.
However, while it penetrates into their outer layers, the inner cores of the GLNs are almost devoid of signal.
An amino-truncated form of CCN3 devoid of signal peptide has been detected in the nucleus of cancer cells ([ 3, 31, 32] and unpublished data).
Interestingly, slow fibres that form a superficial layer on the lateral side of somites in zebrafish were devoid of signal (Fig. 2F,G).
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