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Preliminary in vitro studies showed that both polyplexes and the pure copolymers of the lowest degree of polymerization of the polypeptide block were devoid of intrinsic cytotoxicity.
Flumazenil (benzodiazepine receptor antagonist) is usually described as devoid of intrinsic action in rodent models of anxiety, such as conditioned conflict paradigms [58], [59], the elevated plus-maze [60], [61], the light/dark choice test [62], the staircase [62], [63], the burying test [64] and ultrasonic vocalisations [65].
Unlike beta blockers, ivabradine is devoid of intrinsic negative inotropic effects and does not affect coronary vasomotion.
Atenolol is a cardioselective beta-1 adrenoceptor blocker devoid of intrinsic sympathomimetic and membrane-stabilizing activities [ 12, 13].
Heteromerization with other ErbB family receptors is required for activation of ErbB-3, which is devoid of intrinsic catalytic activity [ 26].
As ERBB3 is devoid of intrinsic kinase activity, it requires dimerisation with another ERBB receptor for phosphorylation (Guy et al, 1994) and ERBB2 ERBB3 heterodimers provide the most mitogenic and angiogenic signals (Alimandi et al, 1995).
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Mr. Buren, who actually patented the exact width of the stripes (8.7 centimeters or 3.4251968503937 inches) admitted then (some 30 years ago) that they were devoid of any intrinsic merit as visual objects.
It is for this reason that discourse on typology has emerged in a period of crisis and disillusionment with an architecture too easily reliant on given "programs" and "functions" and thus devoid of its intrinsic integrity.
(Mikyö Dorje 2006: 273) Therefore conventional truth is "one that is devoid of an intrinsic reality, rather it is mere name (ming tsam), mere sign (rda tsam), mere linguistic convention (tha snyad tsam), mere conception (rnam par rtog pa tsam) and mere fabrication (sgro btags pa tsam)—one that merely arises or ceases due to the force of the expressions or the conceptual linguistic convention".
Devoid of any intrinsic enzymatic activity, the S100 proteins can nonetheless exert their influence on many intracellular processes through interactions with diverse partners.
Integrins, which are devoid of any intrinsic enzymatic activity, have been demonstrated [ 56**] to transactivate the EGFR in order to generate further cellular responses, most notably adhesion-dependent cell survival.
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