Sentence examples for devoid of functional from inspiring English sources

In principal this generates a protein devoid of functional domains or no protein at all.

The authors concluded that KITL541 represented a SNP devoid of functional importance with no role in tumorigenesis in AF.

The TRPC1−/− cells are devoid of functional TRPC1 protein, but retain mRNA for TRPC1 protein comprising the specific region of the third extra-membrane loop.

Although ER-positive cells are often growth stimulated by low phyto-oestrogen concentrations, stimulatory effects have not been reported in cells devoid of functional ER.

Complementary experiments using the R246Q SRD5A2 construct that is devoid of functional activity did not alter cortisol-mediated suppression of DNL.

The lectin staining also revealed large areas devoid of functional vessels, mainly in the tumour centre, in which no DXR could be delivered during the ILP.

One of the biggest challenges in curing human diseases is that most, 90%%, of the proteome is considered "undruggable"—most proteins are devoid of known functional binding pockets or "druggable hotspots" that drugs can bind to modulate their functions for disease therapy.

This is an experimental model predictive of systemic (cardio vascular side effects [11, 12]; since this model is devoid of a functional central nervous system (see General methods below), one can categorically exclude the compensatory baroreflex mechanisms typically observed in intact or anaesthetized animals.

Cardiomyocytes devoid of a functional integrin-linked kinase protein appear stretched and thin when transplanted into a wild-type heart.

For example, introduction of ARF into cells devoid of any functional p53 and Mdm2 proteins results in cell proliferation arrest (Carnero et al, 2000; Weber et al, 2000).

To determine if formation of this complex was a general characteristic of cells devoid of a functional mitochondrial death pathway we again utilized bax −/− bak1−/− cells.