These models of inducible insulin resistance are of considerable interest, because the results are devoid of any developmental compensation and, thus, bypass any changes that arise from deletion of the insulin receptor during embryonic development.
FrzB -/- mice, although devoid of any overt developmental abnormalities, are more susceptible to chemically-induced OA [ 13].
Importantly, these defined culture conditions are devoid of factors that could obscure analysis of developmental mechanisms or render the resulting tissues incompatible with future clinical applications.
Alternately, our visual observation may have resulted from the fact that some brain regions in mouse (cerebellum and medulla oblongata) and humans (locus coeruleus, pineal gland, cerebellum, medulla oblongata and substantia nigra) are clearly devoid of FOXG1 expression at any developmental stage.
Single mutant plants devoid of P5CS1 did not show any developmental defects.
They belong to a hindbrain subregion that is devoid of overt rhombomeric limits, and adjacent developmental units tend to be homogeneous in their histogenesis, irrespective of the local differential patterns of expression of Hox gene paralog groups (see Marín et al. 2008).
The concept of developmental biology.
In vertebrate genomes, regions containing developmental genes, such as Hox clusters, are usually devoid of transposable elements [ 37], suggesting the presence of a constraint against the invasion of foreign elements into a region essential for development.
These observations are also in line with the idea that these developmental-related genes are more likely to locate in large genomic domains devoid of DNA methylation in most lineages (Xie et al., 2013).
