Since the MRE is created only after the introduction of the variant allele, the original sequence of the 3′UTR should be devoid of that particular MRE.
While homologs are present in many bacterial and eukaryotic genomes (Denver et al. 2003), mammals appear to be devoid of this particular class of enzyme.
The cardiac risk associated with cisapride use is entirely attributable to its affinity for the hERG channel which results in QT prolongation, and is enhanced by concomitant use of inhibitors of CYP, the principal pathway in cisapride metabolism.,,,,,,,,,,,, Hence, 5-HT4 receptor agonists without affinity for the hERG channel are devoid of this particular arrhythmogenic risk.
In order to identify which domain of Apaf-1 serves as the binding site for TCTP, we generated variants of full-length Apaf-1 devoid of some particular domain(s) present in Apaf-1, for example APAF-530 (residues 1-530), APAF-420 (residues 1-420), and APF-97 (residues 1-97), as previously described [ 29].
Greater optimism surrounded the profile of second- and third-generation SERMs, in particular because these drugs appeared devoid of any agonist activity in the endometrium while behaving as potent anti-oestrogens in the breast that retained agonist activity in bone.
Whereas performing the same algorithm (SIS) to a modeled grid devoid of particular facies control, facies tend to be more discrete and are not in accordance with the depositional pattern of the region.
Greek polis government, seen from this perspective, would be a particular case of oligarchic despotism (self-government of a minority) exercised over a majority of individuals devoid of any capacity for self-determination.
