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As summarized above and in Figure 4, the unique microenvironmental niche inhabited by ovarian tumours provides a number of diverse mechanisms for transcriptional activation of Wnt/β-catenin target gene expression, even in histotypes devoid of activating mutations in Wnt pathway components.
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Despite of the sequence similarity, jerdonobin-II was found devoid of plasminogen activating effect.
These results taken together suggest that an ideal compound for surface coating of AuNPs would have denser PEG-based polymers that were devoid of complement activating activity.
The cell migration assays were performed with Naja mocambique venom PLA2 (sPLA2 with high catalytic activity), bothropstoxin-I (sPLA2 devoid of catalytic activity) and platelet-activating factor (PAF), using a 48-well microchemotaxis chamber.
Here, we remove all doubt that cells devoid of Rab11 may activate Notch in their neighbors.
Indeed, results presented herein demonstrate that laboratory-prepared meningococcal CPS devoid of LPS can activate human and murine macrophages as assessed by release of cytokines and NO through TLR2- and TLR4-MD2 depathwayspathways.
As the purified GBS pigment, which is devoid of nucleic acids, activates the NLRP3 inflammasome and induces pyroptosis, these results suggest that GBS pigment can induce pyroptosis even in the absence of RNA.
This model explains why C-Raf mutants devoid of kinase activity cannot function as activators, and why B-Raf can activate Mek directly as a homodimer [23].
Conversely, CD4+CD25highGITR− cells showed much lower levels of CD62L, thereby suggesting that this subset includes activated effector T cells or Treg cells devoid of regulatory activity.
Tap water was devoid of hormonal activity.
McolB is apparently devoid of collagenolytic activity.
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