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We tested this hypothesis by infecting TLR2 KO mice with pneumolysin-deficient S. pneumoniae, arguing that these bacteria, devoid of a major TLR4 ligand, predominantly express TLR2 ligands.
If this assumption is true, TLR2 KO mice would display a reduced antibacterial defence against pneumolysin-deficient S. pneumoniae, considering that these modified bacteria, devoid of a major TLR4 ligand, would primarily express TLR2 ligands.
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On a day devoid of any major economic data points from the eurozone and US, the focus has been on the UK in the wake of this morning's construction PMI which plummeted into contraction territory.
In OHT, at variance from enalapril felodipine, EL combination is almost entirely devoid of any major sympathoexcitatory effect and is associated with an improvement in insulin sensitivity.
Manningham has great footwork and is devoid of any major weaknesses.
They show Clinton and her staff used an informal way to exchange sensitive information, but otherwise the release is devoid of any major revelations.
The researchers from the Elkab Desert Survey Project — a joint mission of Yale and the Royal Museums of Art and History Brussels working in collaboration with the Ministry of Antiquities and the Inspectorate of Edfu — surveyed the area of Bir Umm Tineidba, once thought to be devoid of any major archaeological remains.
Although a few results on FP23 have already been published [ 42], we still decided to include this strain in all experiments to provide the reader with a complete comparative view of the different behaviours of pneumococcal mutants devoid of three major virulence determinants.
We used the cells devoid of flavohemoglobin playing a major role in NO detoxification, S-nitrosoglutathione reductase metabolizing S-nitrosoglutathione and the transcription factor Fzf1p mediating NO response (Liu et al. 2000; Lewinska and Bartosz 2006; Lewinska et al. 2008; Sarver and DeRisi 2005; Foster et al. 2009).
After Tiger Woods' personal indiscretions became public, the championship golfer found himself suddenly devoid of most major sponsorship deals.
Microalgae biofuel was devoid of the major drawbacks associated with oil crops and lignocelluloses-based biofuels.
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