Sentence examples for devoid of a functional from inspiring English sources

This is an experimental model predictive of systemic (cardio vascular side effects [11, 12]; since this model is devoid of a functional central nervous system (see General methods below), one can categorically exclude the compensatory baroreflex mechanisms typically observed in intact or anaesthetized animals.

Cardiomyocytes devoid of a functional integrin-linked kinase protein appear stretched and thin when transplanted into a wild-type heart.

Cardiomyocytes devoid of a functional titin protein are elongated and thin when transplanted into a wild-type heart, resembling a DCM phenotype in zebrafish.

To determine if formation of this complex was a general characteristic of cells devoid of a functional mitochondrial death pathway we again utilized bax −/− bak1−/− cells.

Growth of the heterokaryon in the presence of fpa results in numerical superiority of the nucleus that is devoid of a functional tom20 gene resulting in a reduction of the Tom20 protein in the mitochondria of the culture (See Methods).

Exposure to ER stress inducing agents triggered pro-CASP8 processing in cells devoid of a functional mitochondria-mediated pathway (Fig. 2G and H, Fig. S1B), suggesting that CASP8 may function as the apical caspase in this novel death pathway.

For example, introduction of ARF into cells devoid of any functional p53 and Mdm2 proteins results in cell proliferation arrest (Carnero et al, 2000; Weber et al, 2000).

One of the biggest challenges in curing human diseases is that most, 90%%, of the proteome is considered "undruggable"—most proteins are devoid of known functional binding pockets or "druggable hotspots" that drugs can bind to modulate their functions for disease therapy.

In principal this generates a protein devoid of functional domains or no protein at all.

The authors concluded that KITL541 represented a SNP devoid of functional importance with no role in tumorigenesis in AF.

As mentioned above, SNPs rs1327328 and rs7326018 lie in a position of chromosome 13 devoid of any known functional elements.