While on the Manhattan Project at Columbia University, he devised a compound that even today has widespread industrial uses.
It turned out that her chemist colleague Ann Weber had already devised a compound called sitagliptin that spared these enzymes.
So it devised a new compound this year and the result has been what many consider one of the greatest recent racing seasons.
Although it was discovered in the 1970s, its clinical development was prevented by failure to devise a suitable formulation for this compound and the unpredictable and severe toxicity observed in early clinical trials, in particular myelosuppression, gastrointestinal toxicity, and haemorrhagic cystitis (Gottlieb et al, 1970; Muggia et al, 1972).
From there, Dr. Klee and his collaborators, who include Linda Bartoshuk, director of human research at the university's Center for Smell and Taste, used statistics to correlate people's preferences with the presence, or absence, of particular flavor compounds, to devise a chemical recipe for the ideal tomato.
To devise a mathematical means for identifying compounds with strong in vitro/ in vivo correlation, we extended concepts that have been previously employed in calculating the "baseline regression" that correlated the aquatic toxicity of (some) chemicals with the logarithm of the n-octanol/water partition coefficient (log P) (Klopman et al. 1999, 2000; Mayer and Reichenberg 2006).
This volatility has attracted a large amount of interest to the compound in an attempt to devise a simple method for extracting neptunium from spent nuclear power station fuel rods.
Since we cannot be guaranteed that any of the compounds exhibit this idealized behavior we devised a 'virtual p38 compound' that could be tested experimentally.
Because the material they studied, a thallium-barium-copper oxide compound, hasn't been grown in crystals big enough for neutron scattering, the scientists had to devise a painstaking technical workaround.
The two of you devise a plan.
