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In addition to fabrication constraints, most nanofluidic devices require sophisticated support electronics with sufficient current amplification and noise reduction to achieve high signal-to-noise ratios for the analytes of interest.
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Traditional methods of diagnosis, such as virus culture, enzyme-linked immunoassay, and polymerase chain reaction (PCR), are either time consuming or require sophisticated temperature control devices.
The interactive maps and itineraries would be more valuable within the museum itself, and that would require sophisticated apps for various portable devices.
However, such measurements require sophisticated software to analyse computerized signals, and such software is not available for currently commercialized devices.
Defining eligibility would, of course, require sophisticated fact-finding.
Dismantling his small but devastating force will require sophisticated surveillance.
Generally, simulation methods require sophisticated resources, making them time-consuming.
The method does not require sophisticated and costly equipment.
Meeting these challenges will require sophisticated public-private partnerships.
To accomplish this will require sophisticated marketing thinking.
Most techniques require sophisticated microscopy and very sensitive measurement equipment.
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