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Relevant protocol deviations were defined as; visit to chiropractor or physiotherapist performing manipulation, more than one visit to a regular physiotherapist not performing manipulation, visit to general physician or medical specialist other than just for diagnostic questions (e.g. prescription of other pain medication or facet joint injection) or more than two visits to alternative medicine.
Children with a height-for-age z-score below -2 standard deviations but above -3 standard deviations were defined as moderately stunted, and those below -3 standard deviations were defined as severely stunted.
For the quality control strains, deviations were defined as values that exceeded the quality control range of the strain.
Process deviations were defined as situations where an aspect of health care had not been executed correctly (e.g., "right side not marked" or "contrast allergy not checked").
Major protocol deviations were defined as AAD treatment after the ablation procedure, redo procedures before the 6-month follow-up, crossover, and LA ablation strategies other than PV isolation.
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Paraphilias, or sexual deviations, are defined as unusual fantasies, urges, or behaviours that are recurrent and sexually arousing.
The mean baseline noise plus six standard deviations was defined as the theoretical LOQ.
The soft sign tests in NUBU are the same for all ages; deviations are defined as performance inferior to 85% of the normally developing children.
Individual samples were classified as seropositive or seronegative against each antigen using a mixture model, whereby the mean of the seronegative distribution plus three standard deviations was defined as the seropositive cutoff.
Mean values of their absorbance (× 1000) plus twice the standard deviation were defined as cut-off values, and these cut-off values were also confirmed by ROC (receiver operating curve) analysis (Additional file 1: Figure S1).
A possibilistic absolute deviation is defined as the risk control of portfolio.
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