Each index was then standardised, with the average score across OECD countries set at zero and the standard deviation set at one.
Figure 7 (a) 10th frame of the noisy "Interview" sequence, (b) frame denoised using method from [10], (c) result of [27]with noise level estimated using [30], (d) the result of [27]with noise standard deviation set to the maximal standard deviation of noise (equal to 20), (e) frame denoised using the proposed method, (f) noise free frame.
For the geological calibration point (emergence of Grande Comore), we used a normal distribution with the mean and standard deviation set to 0.5 mya and 0.1 mya, respectively.
In this analysis the age of the root of the species tree was defined with a lognormal prior, using a mean set to 2.9 million years ago (Mya) and standard deviation set to 0.4.
Raw data from each individual channel of each array was also subjected to principle components analysis (PCA) and hierarchical clustering following normalisation of data (log2, mean set to 0 and standard deviation set to 1) using Partek software.
The resulting protein fold changes were normalized; population median and standard deviation set the threshold ratio to consider, with a p value < 0.1, a protein as differentially expressed in each condition (HT-29 cells treated with CIGB-552 for 40 min, 2 h, or 5 h) with respect to control (untreated HT-29 cells).
To assess the impact of simultaneous changes in all model parameters, we also performed multivariate uncertanty analysis, varying all parameter estimates over beta distributions (for variables bounded between 0 and 1) or gamma distributions (for variables bounded between 0 and infinity), with means set to expected parameter values and standard deviations set to 12.5% of expected parameter values.
Temporal variance of disturbance was imposed by selecting the actual number of individuals to be removed at each time step from a normal distribution with mean 400 individuals and standard deviations set as 5, 10 and 20% of the mean for the LV, MV and HV treatments, respectively.
The R for each standard curve was ≥ 0.99, with acceptable standard deviations set at 0.25 (for the Ct values).
A total of 5,000 combinations of input parameters have been tested using the baseline values from the design report and normal distributions of the important variables with standard deviations set to the uncertainties calculated in this work.
