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This deviation is expected to turn the team's only true weakness into a strength.
This also suggests that when the effective segregation parameter ϕχABN is fixed, a larger deviation is expected as χABN increases (i.e. ϕ decreases).
This deviation is expected mainly due to the effect of particle size in X-ray scattering.
The standard deviation is expected to be sensitive to the sampled surface as the lower part of the specimen is subjected to a larger strain.
If longer protofilaments tend to shorten more quickly and the shorter less, the standard deviation is expected to be reduced.
This deviation is expected since the NIRS measured THC changes do not directly correspond to the blood flow changes [ 25].
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On the contrary, if the sample size is small, a mean value far different to the theoretical value and a high standard deviation are expected.
The noninferiority margin was estimated to be 20%, and the standard deviation was expected to be 18.5.
This deviation was expected as the HED reaction as reversible (see below) and irreversible mass action kinetics were used in our models because the equilibrium constant for this reaction was not known.
We hypothesize that participants in the usual care group will show mean changes in the aforementioned variables comparable to those founded in the GOSPEL study, while patients in ACT condition will achieve better results on these primary outcomes with a medium between-group effect size (a standardized mean difference between mean changes of at least 0.3 standard deviations is expected).
However, simulations show that the universal calibration is not strictly valid and deviations are expected in particular when the global flexibility of standard and sample are different.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com