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The deviation from the extended conformation in the first cluster is caused by a bend at residue +3 in the direction of the CD loop and away from the hydrophobic pocket of the SH2 domain (Figure 5).
As the size of the side chain of pTyr+3 residue decreases, so does the population of the first cluster, and the deviation from the extended conformation increases (CA-RMSD of 1.5 Å for pYEEL and pYEEV, and 2 Å for pYEEA).
Similar(58)
Specifically, the deviations from the extended conformation observed in the SH2-bound peptides pYEEA and pYEEG are similar to those reported in a more sophisticated, parallel tempering dynamics study of Ala and Gly mutants of pYEEI bound to Src SH2 with implicit solvent and a different energy function [31].
As the linker becomes longer and more flexible, this deviation from the fully extended idealized conformation becomes more profound.
The vertical bars extend to one standard deviation from the average.
No deviation from the formula is permitted.
There is no deviation from the ritual.
What happened then was a sharp deviation from the norm.
But the opera featured one major deviation from the form.
There's no deviation from the TV format.
Traceable cause suggests a deviation from the norm.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com