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Smaller population size, no deviation from recommended appropriate comparative therapy and the incorporation of HRQoL-data were associated with a lower discount on the price at launch.
This is a major deviation from recommended practice, the type of which could only be revealed in an observational study.
Many factors underlie this deviation from recommended guidelines, including worsening clinical condition, reported penicillin allergy as well as multiple co-morbidities.
A systematic review of studies addressing physicians' barriers to guideline adherence, identified physicians' lack of awareness of a guideline's existence and lack of familiarity with the guideline as the leading causes of deviation from recommended therapy [ 11].
In other instances there are limitations due to systemic constraints which do not allow for flexibility in prescribing practices in specific clinical contexts where deviation from recommended doses may be clinically indicated.
Pediatric medication dosing has been recognized as a high-error activity with the potential to cause serious harm, and it has been found that the Broselow tape and color-coded materials would result in a decrease in deviation from recommended medication doses and equipment sizes and an increase in physician comfort level [16].
Similar(52)
The TABS measures both intentional and unintentional deviations from recommended management and has been shown to have greater incremental validity than other self-reported adherence measures [ 17].
Violations (intentional deviations from recommended practice (eg, clinical procedures)): Routine (eg, cutting corners as habitual behaviour), Optimising (furthering personal rather task-orientated goals), Necessary (violation essential to perform task appropriately).
Gundanna et al 16 reported a 0.6% bowel injury rate in patients treated with AxiaLIF, with 42% of these perforations due to frank surgeon error or deviations from recommended procedural steps.
It is calculated from the point of view that a lower value of it signifies less deviation from the recommended values of parameters included and more good quality water for human consumption or vice versa.
Deviation from the recommended range of -2.5 to +2.5 indicating misfit are bold.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com