Therefore, PRMT5 and PRMT4 are likely to regulate pre-mRNA splicing, at least in part, by contributing to stabilizing weak RNA-RNA interactions between donor splice sites that deviate from the consensus sequence, and the sequence present in the U1 SnRNA that is complementary to the consensus donor splice-site sequence.
RNA editing alters the nucleotide sequence of an RNA molecule so that it deviates from the sequence of its DNA template and provides a novel post-transcriptional regulatory system in organelles (Tillich et al. 2006).
Consequently, we cannot exclude the presence of less conventional GRE loci in the transcripts, or the presence of GREs that deviate from the consensus sequence or are located outside the queried sequence.
Failure to trim off the primer sequences will result in final sequences which include these ambiguities and hence deviate from the true sequence.
For sequences that deviated from the sequences of reported OR proteins, the methionine and stop codon most similar in sequence context to those of the coding sequences of known OR proteins were selected as the start and end of the coding regions.
Such as, in communication channels, discrete signals generated by a specific sequence from a source could be corrupted by Gaussian noise in the transmission process; so, the received signals could deviate from the signal sequence [10].
However, this approach did not account for the majority of genomic instances, many of which deviate from the consensus sequence.
This indicates that the splicing events predominantly regulated by PRMT5 alone, or simultaneously by PRMT5 or PRMT4, are enriched in weak splice sites that deviate from the consensus sequence.
Attacks will be detected if the system call sequence deviates from the known sequence.
To determine whether the copy number of a chromosome within a patient sample deviated from normal, the sequence tag density (i.e. number of sequence tag per 50 kb bin) distribution of a chromosome was compared to all other chromosomes (except chromosome Y).
