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A number of right hemisphere regions also responded more strongly to deviant trials than to standards.
Novelty responses to deviant trials were also observed in right frontal regions and hippocampus.
In the current experiment, an anterior region of right hippocampus responded preferentially to deviant trials, consistent with this role.
Trains of four identical stimuli (standard trials) and trains of three identical stimuli followed by a stimulus from a different phonetic category (deviant trials) were presented.
A minimum of 150 artifact-free deviant trials were recorded in each block, thus resulting in slightly over 60′ experimental time.
Note: DEV > STD = increased response to deviant trials relative to standard trials; STG = superior temporal gyrus; SMG = supramarginal gyrus; MFG = middle frontal gyrus; BA = Brodmann's Area.
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Sixteen deviant response trials were randomly sampled from the experimental conditions and responses to these trials were modeled with a separate nuisance regressor of no interest.
Volunteers were instructed to monitor the stimulus set for infrequent deviant response trials (1 of the 8 experimental videos, rotated 4° from the upright position) and responded to detected deviants with a button press.
The deviant response trials were drawn from all experimental conditions, and the degree of rotation was chosen after behavioral pilot tests to produce an attentionally demanding task without ceiling effects.
Volunteers were asked to detect the occasional 4° rotation of the video stimuli and were able to detect such deviant response trials adequately (mean accuracy 71%, standard error 4%).
In each block, equal numbers of standard, deviant and silent trials were run.
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