The morphological grade determined from the specimens examined by electron microscopy was scored on a six-point scale previously described by Billingham et al (1978) (Bristow et al, 1982): in grade 0, cells are normal; in grade 1, 1.5, 2 and 2.5 deviant cells are <5, 5 15, 16 25 and 26 35%, respectively; in grade 3, cell damage is >35%.
Dysregulation of the cell cycle governs deviant cell proliferation in cancer.
In order to have the different cell (line)s at day 4 after plating in the same state of subconfluency, hBMSC were plated with deviant cell density considering that the cells are larger in size [ 19].
The feature of self-renewal in stem cells is shared with tumor cells, and deviant function of the stem cell regulatory networks may, in complex ways, contribute to malignant transformation and the establishment of a cancer stem cell-like phenotype.
This pathway may even eliminate deviant tumor cells generated by inactivating mutations of tumor suppressor genes [ 113, 114].
Cotreatment with DEX led to a 6.2-fold reduction of deviant cardiac cells (95% CI 1.9 20.0) compared to the mice treated with DOX alone.
Importantly, deviant Th cell activity is implicated in numerous autoimmune and allergic diseases, prompting research into the molecular underpinnings of Th effector subset development [ 5].
Deviant cytokine patterns and hormonal factors and abnormal T cell and B cell function with a wide range of autoantibodies and immune complexes (ICs) have all been implicated in the aetiopathogenesis of SLE [ 2].
Among all the members of non-protein-coding HGs, gas5 is of interest because of its large snoRNA-coding capability and deviant accumulation in cells undergoing serum starvation or density arrest [ 24].
Cells that disseminate through foreign stroma experience more deviant conditions, and upon reaching the parenchyma of distant organs need to adapt to the non-permissive matrix in the foreign tissue.
