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The closely held CarboGen, which develops drug production processes, had 1999 sales of more than $20 million.
But in resource-limited settings, if a high percentage of the population develops drug resistance we could see large increases in Aids-related deaths and higher healthcare costs.
Pseudomonas aeruginosa infection is difficult to treat because of its drug resistance, but how it develops drug resistance remains largely unknown.
However in both cases, the tumor subsequently treated with the drug, which is targeted to the secondary or third mutation, finally develops drug resistance, manifesting as holding the third or tertiary mutation.
Malignant melanoma is an aggressive tumor type that often develops drug resistance to targeted therapeutics.
These failings stem from the direct effect of the drugs, and develop gradually, as the cancer adapts to treatment and develops drug resistance.
Similar(48)
Gloucester, based in Cambridge, Mass., develops drugs for blood cancers with limited treatment options.
However, HIV-1 develops drug-resistance which decreases the affinity of Nelfinavir for the binding pocket of Protease.
Alza Corp., which develops drug-delivery technology (like what is used in nicotine skin patches), has been doing this for years.
To illustrate the typical outbreaks of wild-type and resistant infections, we inserted the following parameter values: γT = 0.0036 day−1; γU = 0.00036 day−1; δr = 0.2; δrH = 0.9; which correspond to probability 5×10−4 that a treated individual infected with the wild-type virus develops drug-resistance with high transmission fitness.
It should also be considered that Plasmodium falciparum, when exposed to drug-induced selective pressure, develops drug-resistance (e.g. pyrimethamine and chloroquine) [ 48].
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