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Once a tumor develops beyond 2 mm in diameter, the development of tumor vasculature is stimulated by the "angiogenic switch," an imbalance of proangiogenic and antiangiogenic factors (Brem et al. 1976, 1999; Carmeliet & Jain 2000; Herbst & Fidler 2000; Liekens et al. 2001; Carmeliet 2003).
So while 'normal' ageing was inherently pathological in this view, an individual developed dementia only once 'the degenerative process measured by plaque counts develops beyond a certain threshold point' (Blessed, Tomlinson and Roth, 1968: 805).
This kid never develops beyond our first view of him.
As a character Pedro never develops beyond a credulous, good-hearted cipher.
It is here, where Julie's love for Ibrahim develops beyond him and ultimately leaves him behind, that the book is most moving though also, to the sceptical reader, most uncomfortable.
While headteachers have always communicated, Beer says the existence of a formal infrastructure has been crucial in embedding this collaborative approach so it develops beyond an ad hoc way of working and doesn't just become reliant on one or two individuals taking the lead.
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Peramorphic descendants develop "beyond" the ancestor; padomorphic descendants retain juvenile ancestral features.
My role with BP eventually developed beyond just writing into overseeing research and development, managing the statistical databases, leading programming teams, and analyzing baseball statistics.
Many auditory skills continue to develop beyond infancy and even into adolescence, but the factors underlying this prolonged development remain poorly understood.
None developed beyond "It's been nice, thanks".
"Sometimes matters develop beyond our control," he said.
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