Exact(3)
In an attempt to resolve this apparent paradox, we superimposed diabetes in a rat model that develops accelerated renal injury in response to VEGF blockade.
Here, we show that the POKO mouse is a model with robust and uniform kidney injury that develops accelerated features of diabetic nephropathy at the age of 4 weeks in a context of glucolipotoxicity, characterized by higher plasma levels of glucose and triglycerides than their ob/ob littermates.
In order to determine whether altered eNOS activity may underlie the differential response to VEGF blockade with experimental diabetes, we exploited a rodent model that develops accelerated renal injury when challenged by VEGF receptor kinase inhibition, the transgenic (mRen-2 27 mRen-2 272).
Similar(57)
Importantly, heterozygotes on 3-month HCHF diets developed accelerated lesions in the aortas and coronary arteries.
In this context, developing accelerated stress testing (AST) in order to assess quickly the long-term behavior of a semiconductor becomes extremely useful.
In this paper, the prediction of long-term strength of CFRP laminates for innovative marine use under water absorption conditions were performed by our developed accelerated testing methodology.
Due to the high cost of the development of new chemical entities and the current low overall productivity of obtaining successful candidates, the pharmaceutical industry is being required to develop accelerated POC strategies.
Although atherosclerosis occurs to a certain degree in all people, people with FH may develop accelerated atherosclerosis due to the excess level of LDL.
However, APP/CCR2−/− mice develop accelerated amyloid angiopathy and shortened lifespans.
Sirt3− / − mice developed accelerated obesity, insulin resistance, and hyperlipidemia.
Mice with targeted deletion of Fbx2 develop accelerated, age-related hearing loss starting at 2 months.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com