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This finding has important clinical implications; particularly for the use of estrogen deprivation as long-term therapy, and it suggest that, if and when resistance develops, a strategy of treatment with estrogen combined with BSO may be effective in sensitizing resistant cells to apoptosis.
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To investigate the role and mechanistic pathway of Rac1 involvement in pathological changes of OA chondrocytes in vitro and OA development in vivo, as well as to develop a strategy of modulating Rac1 activity for OA treatment.
In order to achieve our goal we developed a strategy of heavy tweet collection followed by a significant analysis.
I developed a strategy of reiteration and cross-reference to help student internalize the material and attain solid knowledge.
Ms. Piazza developed a strategy of flattering an actor until she sensed that the handler had lost attention.
"He is spending an awful lot of time and money and capital shooting other people's foxes, rather than developing a strategy of his own," said Laws.
In developing a strategy of access to GIS, we discovered a hybrid computer system is necessary for all members to effectively gain access.
Under these difficult circumstances, Elizabeth developed a strategy of rule that blended imperious command with an extravagant, histrionic cult of love.
But the tactic was rare until the second term of President Ronald Reagan, whose legal team developed a strategy of issuing the statements more frequently to increase presidential power.
As an Astor Home psychologist wrote in 1984, Lamont "had developed a strategy of maintaining distance or, when threatened by the possibility of attachment, of rejecting the other party before that person could reject him".
Mr. Pincus and his longtime partner, John L. Vogelstein, who joined the company from Lazard Frères, developed a strategy of investing in a range of companies of different sizes rather than focusing solely on start-ups, as many venture capital firms did.
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