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By reviewing recent developments, we found that comprehensive mapping of the protein metabolite interaction space can be achieved eventually using existing methods, amongst which proteomics techniques to assess cell wide protein property changes in response to metabolite treatment currently offer the highest potential.
In new developments, we found out that in low-dense settlements relying on stand-alone single-family houses, the energy demand for streets, sewage systems and other related technical infrastructures in the settlement can exceed 50% of the total energy demand of a settlement, causing up to 90% of the life cycle CO2 emissions and up to 80% of the ecological footprint.
Consistent with these preclinical developments, we found that YB-1 is strongly correlated with EGFR in primary breast tumours by screening a tissue microarray of ~490 cases [ 4].
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Consistent with a significant increase in the number of developing follicles during ovary development, we found that a majority of the differentially-expressed TGF-β genes and their receptor genes were substantially upregulated in the adult ovary compared to the infant ovary.
Consistent with a role for FGF20 in early feather development, we found that it is expressed in the developing feather placodes.
Although we found that ezrin is dispensable for lymphoid development, we found an intriguing pattern of ERM protein expression in developing thymocytes.
Although Sox9 plays an important role during salivary gland development, we found that Sox9 could not induce epithelial budding from ESC-derived oral ectoderm.
By inactivating calcineurin during haematopoietic development, we found that although this signalling pathway has an important, non-redundant role in the regulation of lymphocyte developmental checkpoints, it is not essential for the development of blood myeloid lineages.
Second, at the interstices between the different phases of development we found that ventures face "critical junctures" in terms of the resources and capabilities they need to acquire to progress to the next phase.
In this study spanning a decade of diabetes drug development, we found that fewer diabetes drugs entered phase II testing than would have been expected based on trends in nondiabetes drugs after the publication of an FDA guidance document recommending that diabetes drugs undergo cardiovascular safety testing.
Among previously reported genes related to leaf hair development, we found GL6, related to pubescence growth and development, which was fine-mapped on chromosome 6 (Zeng et al. 2013), and Hla, related to long hair production, which was mapped on chromosome 6 by classical linkage analysis and may be complementary with Hlb (Nagao et al. 1960).
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