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To this date, clinical developments of drug combinations are typically through trial and error or guided by insight into the dysregulated signaling pathways in specific diseases.
Wheat germ agglutinin is an N-acetyl-glucosamine and sialic acid-specific lectin, which is known for many years to be transported to the Golgi apparatus in retrograde direction (e.g. Gonatas et al. 1977; Stieber et al. 1984); it is also used in connection with the developments of drug delivery systems (Lochner et al. 2003; Weissenböck et al. 2004).
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Understanding the mechanisms underlying development of drug resistance is critical to develop more effective treatment regimens.
The development of drug courts may meet resistance from some Republicans in Congress.
Clinical efficacy of many anti-cancer drugs is limited by the development of drug resistance [12].
A major limitation in cancer treatment is the development of drug resistance.
Slowly eliminated antimalarial drugs may be most prone to development of drug resistance [33].
A well-recognized limitation of currently available antivirals is the risk of development of drug resistance.
The efficacy of oxaliplatin in cancer chemotherapy is limited by the development of drug resistance.
Length of treatment in turn fuels patient non-compliance and development of drug resistant strains [7].
Nonadherence may lead to virological failure, and increases the risk of development of drug resistance.
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CEO of Professional Science Editing for Scientists @ prosciediting.com