In development of the hierarchy some disciplinary areas were discrete and some overlapped.
The tomato mutants highlighted this aspect, that is, ethylene is important for many aspects of fruit ripening [ 11- 13] but other factors, such as the MADS box transcription factors, are higher in the hierarchy of development regulation, and act also independently of the ethylene pathway [ 11, 14].
Together with the fact that cebpa is expressed prior to spib, this result suggests that cebpa may act upstream of spib in the hierarchy of myeloid development.
ASCL1 is another transcription factor that is expressed in the subcortical telencephalon and is thought to function high up in the hierarchy of cortical interneuron development.
It was possible to discern a hierarchy of importance for cytokines in rheumatoid arthritis, which eventually led to the development of drugs to target the most important cytokines in the hierarchy, notably TNF-α and IL-1.
They report that LSC are not enriched in blast populations expressing either CD34 or CD10, both markers of immaturity in the hierarchy of normal B cell development.
Worker ovarian development was affected both by "group-size" and "worker position in the hierarchy" (Table 1; two-way ANOVA for group-size: f2,66 = 5.27, p = 0.007 for; for position in hierarchy: f1,66 = 5.92, p = 0.017; for group-size*position in hierarchy: f2,66 = 2.53, p = 0.087).
These observations support the hypothesis that Nrf2 sits high in the hierarchy of events leading to the development of a fully vascularized tumour.
Hence, this paper provides a significant development in the theory of three-term difference boundary value problems in regard to singularities and asymptotics in the hierarchy structure.
