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Sociodemographic, clinical and developmental variables are analyzed.
To minimize developmental variables in fetal versus adult TGF-β regulation, we narrowed our study to wounded fetal animals.
Therefore, in the development of pediatric protocols and appropriate dosing in children, it is essential to develop a strategy for addressing the developmental variables that affect drug exposure and to incorporate them into study design.
Yet, none of the child developmental variables remained in the final models.
Using the full range of development, we found significant quadratic fits between cognitive outcomes and developmental variables (Table 3; illustrated for standing in Fig 3).
If a principal component was strongly influenced by development, then its score would be expected to demonstrate a pattern of change with respect to both developmental variables.
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We tested whether relationships between development and cognitive function deviated from linearity by adding a quadratic term (the square of the developmental variable) to the above regression models.
The developmental variable manipulated was different in the two studies, brood size in one case and position within the brood in the other.
As we use developmental precocity as a proxy measure of neural development, we also included a control developmental variable, age of teething, which we predicted would have no relationship to subsequent cognition.
Of these, 3,969 (84%) subjects had information on at least one developmental variable in addition to complete information on all confounders, and could therefore be included in the analysis.
The biomarkers present in the tricarboxylic acid cycle (malate, succinate and citrate) are all strong negative loaders on Principal Component 2. This component tends to vary more with days post-emergence than with the more strictly developmental variable of height of sampling of the tissue.
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CEO of Professional Science Editing for Scientists @ prosciediting.com