Sentence examples for developmental turnover from inspiring English sources

The active form of ADAMTS-4 (but not ADAMTS-5) has been reported to co-localise with ADAMTS-mediated aggrecan cleavage in developing long bones in the rat, implying that ADAMTS-4 mediates the developmental turnover of aggrecan during long bone formation [ 53].

To further investigate the dynamics and mechanisms underlying these effects, and since in vivo imaging is precluded by the need of anesthesia, we performed repetitive confocal imaging of eGFP transfected CA1 pyramidal neurons in 2 3 weeks old hippocampal slice cultures, a model also showing a developmental regulation of spine turnover [24].

MicroRNA regulation is known to be crucial for many processes involved in animal development: Specific microRNAs play a role in developmental timing, maternal transcript turnover, cell differentiation, morphogenesis, organogenesis, and apoptosis (reviewed in Kloosterman and Plasterk 2006).

We demonstrate the generation of caspase-induced neoepitopes in a) an in vitro neuronal culture model using nerve growth factor-deprivation-induced degeneration and b) an in vivo model using ethanol-induced neuronal apoptosis, and c) during normal developmental pruning and physiological turnover of neurons.

These cleavage events occur in a variety of contexts involving axon degeneration, including a) in vitro in neuronal cultures induced to undergo apoptosis via nerve growth factor deprivation, b) in vivo after ethanol-induced apoptosis as well as during developmental apoptosis and physiological turnover of neurons, and c) in human brain after acute or subacute hypoxic-ischemic injury.

These pathfinding and fasciculation defects reflect what we suspect: Ppt1-mediated turnover of palmitoylated developmental proteins is necessary throughout development such that its loss is cumulative and progressive.

Whether this minute amount of protein resides predominantly in the lysosomes and/or synapses for the turnover of palmitoylated developmental proteins, it is necessary and its absence would most likely have similar consequences.

Given the role of Dis3 in regulating a defined subset of the S2 cell transcriptome, we hypothesized that Dis3 depletion affects fly development by perturbing either the expression, processing, and/or turnover of vital developmental transcripts.

In vicilin metabolism, synthesis and degradation, the antagonistic processes of protein turnover, are temporarily separated, occurring during different developmental stages.

Alternatively, regulated periods of imbalances between turnover events (proliferation, differentiation and loss) drive developmental and adaptive changes in the epithelial tissue architecture and function.

Developmental cues also play important roles in conferring metabolic turnover of carotenoids [ 28].