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Dronc is the only CARD-carrying caspase in the fly and can associate with the adaptor molecule, Ark, to form a multi-subunit apoptosome complex in response to developmental triggers of apoptosis as well as toxic stimuli [20], [21].
More particularly, programmed changes in the germ cell DNA methylation state serve as developmental triggers for gametogenesis, as illustrated by the two demethylation waves in developing PGCs (Hajkova et al., 2002).
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The precise developmental trigger that results in fusion of the cavum remains uncertain.
These results indicate that metamorphosis is an important developmental trigger to promote taurine transport in Senegalese sole larval tissues.
Remarkably, by embedding the endogenous PAD1 protein into the VSG coat, the ES attenuated trypanosomes became fully responsive to the developmental trigger cis-aconitate.
Together these data provide strong evidence that glucocorticoids represent an important developmental trigger and that their effects are mediated at the level of DNA methylation.
Results also showed that Senegalese sole metamorphosis is an important developmental trigger to promote taurine transport, especially in larval muscle tissues.
Together these data provide strong evidence that glucocorticoids are an important developmental trigger and that their effects are mediated, at least in part, by the level of DNA methylation in the genome.
Moreover, results showed that Senegalese sole metamorphosis is an important developmental trigger to promote taurine transport in larvae, especially in muscle tissues, which may be important for larval growth.
Supporting this hypothesis, a mutagenized 4m-MIR168a gexpressingsing a compensatory miRNA rescues developmental defects triggered by a 4m-AGO1 gene.
Nevertheless, a mutagenized 4m-MIR168b gexpressingsing the same compensatory miRNA also rescues developmental defects triggered by 4m-AGO1 expression, and the mir168a-2 mutant develops normally under non-stressful conditions.
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