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The presence of mucin should be carefully evaluated in developmental trials of new agents for treating colorectal cancer.
When appropriate-sized equipment is used in the developmental trials, process scale-up with continuous systems can be as simplistic as just running the unit for longer periods of time.
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Developmental field trials enhance the empirical basis for stating that psychiatric classifications are evidence based and they ultimately contribute to the improvement of clinical care for patients.
Wakelee sought out individuals who had conducted phase I developmental therapeutic trials; her new mentors worked with her to hone her ideas into testable hypotheses.
A crucial component of an empirically guided diagnostic revision process is the use of developmental field trials in which data are collected from users regarding the feasibility, reliability, validity, and clinical utility of proposed changes that can assist in refining the proposals before they are finalised.
Should our hypotheses prove correct, then favorable outcomes from our developmental clinical trial will inform the design and justification for undertaking a large multicenter outcome trial to further validate these initial findings.
Our developmental clinical trial will address the feasibility of FFR measurement in NSTEMI and the influence of FFR disclosure on treatment decisions and health and economic outcomes.
There was a stronger effect of developmental treatment on trial consumption, with DIS birds eating significantly more food than ADV birds (Fig. 2, Appendix Table A1, Cohen's d = 0.691, Model 4).
Developmental acclimation in these trials differed from the earlier laboratory trials on critical thermal limits and activity, mainly in that moths were acclimated for their entire egg-larval duration owing to logistic constraints on climate chambers.
Such investigations may allow us to identify adequate patient subsets and new therapeutic targets for trials of developmental therapeutics.
Further investigation is necessary to assess the responsiveness of the VOAA-DDD in therapeutic trials targeting developmental disregard as well as to determine its clinimetric properties in children older than 8 years of age.
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