We describe examples of genomic control circuits that underlie developmental transitions and cellular activation states within the immune system.
Elevated ambient temperature accelerates growth and developmental transitions [1] while compromising plant defenses, leading to increased susceptibility [2, 3].
N6-methyladenosine (m6A) affects multiple aspects of mRNA metabolism and regulates developmental transitions by promoting mRNA decay.
Developmental events represented developmental transitions such as the first appearance of a structure (e.g., heart primordia) or some morphogenetic movement (e.g., fusion of the neural folds).
Two years ago, his group was among the first to discover 21-nucleotide RNA duplexes-- microRNAs --that trigger duplexes-- microRNAs --thatn the worm by switching off target genes.
Functional differentiation of chromatin structure is regulated by multiple and hierarchical epigenetic modifications established at critical developmental transitions by chromatin remodeling proteins and histone post-translational modifications.
As a consequence of the resulting adaptation processes, they evolved highly complex life-cycles in which many developmental transitions were initiated and controlled by host-derived signals.
Changes to both global and base-specific patterns of DNA methylation are hallmarks of key developmental transitions in the embryo and are characteristic of each defined cell lineage.
However, we currently lack a detailed understanding of how chromatin and gene expression patterns are coordinated during developmental transitions in the cardiac lineage.
Therefore, a plant must time each of its developmental transitions (from seed to seedling, for example, or from bud to flower) so that the next life stage experiences an environment that favors growth and maximizes fitness.
Moreover, several miRNAs may serve as temporally regulated switches that tightly modulate developmental transitions.
