Studies of the effects of factor interactions on behavior variance are a starting point for developmental approaches.
These types of comparisons make it possible to target general versus species-specific developmental processes, thus providing as starting point for investigation into the evolutionary dynamics affecting maternally expressed genes.
In view of the accessibility of the zebrafish as a model for developmental studies, our data provides the starting point for experiments to dissect the molecular pathway producing muscle weakness and wasting in DM.
In this study, we have provided a starting point by defining the developmental stages of precursor cells that are competent for cone transplantation.
Since the discovery of mice and Drosophila Hox clusters [1] [3] the evolutionary conservation of the Hox axial patterning system has been the starting point of a conceptual framework in evolutionary developmental biology (evo-devo).
Creating lists of the differentially expressed genes is only the starting point of gaining biological insights into experimental systems, developmental stages, or specific disease scenarios.
The dual effect of a novel environment on phenotypic plasticity – simultaneous exposure of "hidden" developmental variation and strong selection on this variation – can be a starting point in the evolutionary persistence of some adaptations [ 3- 6].
Environmental induction of novel phenotypes, where phenotypic retention of adaptive developmental variation is enabled by organismal complexity and homeostasis, can be a starting point in the evolution of some adaptations, but empirical examples are rare.
We take as our starting point the proposition that maternal stress and depression adversely impact on the developmental origins of health and disease.
Our model mouse will be valuable not only for therapeutic studies but also provides a starting point for more detailed genetic analysis directed toward understanding the etiology of developmental brain disorders.
