Exact(34)
Additionally, Notch2 provided a tissue-specific developmental signal for the CD11b CDC03 DC population in the small intestine and colon, which supported optimal differentiation of Th17 cells, a major effector CD4 population in this tissue type (Lewis et al., 2011).
Here we summarize how the early Hox cis-regulatory landscape becomes active upon receiving the appropriate developmental signal, and we discuss the importance of the local topological segmentation of the HoxA cluster during early Hox activation.
Because these pathways are mostly attributed to lung development and are normally thought to be quiescent in the adult lung, this raises the question of why these pathways become aberrant in the adult and whether pre- or postnatal insults impact developmental signal activity early on, thus contributing to an increased susceptibility for chronic lung diseases later in life [7, 18].
Now, researchers led by Philip Beachy of the Johns Hopkins University School of Medicine in Baltimore are studying how these teratogens affected a developmental signal called Sonic hedgehog (Shh), which guides the development of many parts of the body, including the forebrain and the face.
The precise function of this extension remains unknown, but is thought to aid in generating an essential developmental signal, the D-signal.
Endogenous tasiRNAs are thus mediators of a mobile developmental signal and might provide effective gene silencing at a distance beyond the reach of most miRNAs.
Similar(26)
Chloroplast transcription change in large-scale in response to environmental or developmental signals (Barkan 2011).
However, such promoters are often either leaky or controlled by developmental signals (Van Loon et al. 2006).
The developmental signals and epigenetic mechanisms underlying this early activation remained unsolved until recently.
This replication behavior suggests that developmental signals can separately influence the timing of different satellite sequences.
Developmental signals such as Wnts are often presented to cells in an oriented manner.
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