However, the relationship among these phenomena remains unclear because it is difficult to experimentally show how the developmental shift of inhibitory transmission influences neural activities and whether the activities promote synapse elimination and neurite pruning.
In this context, mammalian weaning is a developmental shift of small intestinal β- to α-glucosidic substrate digestion, a shift from a carnivorous to an omnivorous diet in human infants.
In angiosperms, heterochronic alterations in cell cycle activity led to the developmental shift in the timing of germ-cell division and resulted in diversified patterns of spermatogenesis and gamete fusion during fertilization [ 4- 6].
The switch from depolarizing to hyperpolarizing GABAA-ergic signaling is triggered through the developmental shift in the balance of chloride cotransporters that either increase (i.e. NKCC1) or decrease (i.e. KCC2) intracellular chloride.
In addition, the overrepresented GO terms reflected the regulation of a major developmental shift: activation of MAPKK activity, negative regulation of ethylene-mediated signaling pathway, and transmembrane receptor protein serine/threonine kinase signaling pathway (Table 2).
Therefore, the change of the expression profile of genes involved in different biochemical pathways observed between wrn-1 gk99 wrn-1 gk99d wild type animutanteflect andurately the difference detected at a specific developmental time point rather than a developmental shift caused by the loss of wild1.
Developmental shifts in the pattern of TE expression have been detected in Drosophila [ 34, 35] and there are numerous host factors that can influence the spatial and temporal regulation of TEs [ 36, 37].
An abrupt developmental shift in callosal modulation of sleep-related spindle bursts coincides with the emergence of excitatory-inhibitory balance and a reduction of somatosensory cortical plasticity.
Because we sampled at only four stages during ontogeny, we cannot identify the exact timing of this developmental shift except to say that it occurred late in embryogenesis (i.e., in the final 25% of the incubation period).
The emergence of this two-process architecture in childhood suggests that the developmental shift from outcome- to intent-based judgment involves a conceptual reorganization within the moral domain.
