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It is therefore important to screen for Nodal/Smad2/3 target genes in ES cells as these represent a developmental relevant context.
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However, transient RNAi with double stranded RNAi or small interfering (si RNA has gained a foothold as a useful technique for gene knock down (if not knock out), including in those developmental stages relevant to infection and pathology in humans (somules, adults and eggs) [52], [53].
Nevertheless, research in community populations can provide insight into developmental issues relevant to the clinical setting [ 35].
The mother or other significant relative or family member(s) was interviewed on developmental issues relevant for the diagnosis.
This paper is concerned with examining simple measures of laterality and hand control including measures of motor function, which may signal developmental deficits relevant to scholastic ability.
A targeted analysis of expression during developmental stages relevant for ear development would be necessary to demonstrate their existence and potential connection with ear phenotype.
A striking example is the long hypomethylated regions enriched with modified H3K27me3 (called, "K27HMD" regions), which are exposed to suppress the expression of key developmental genes relevant to cellular development and differentiation during embryonic stages in vertebrates.
We suppose that the critical loss of early developmental genes relevant to cell-type specification affected the gene networks and led to the invention of a new developmental program where the entry of the entire amoeba to germ-line spores was traded off against the low efficiency of their dispersal due to short and fragile acellular stalks that were unable to support sizable spore balls.
Formative research and developmental research are relevant for all four.
The developmental perspective is relevant in teaching and outreach efforts for the understanding of evolutionary theory today.
Differentiation is accompanied by chromatin remodeling at repetitive elements associated with altered expression of genes in relevant developmental pathways.
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