Hu, B. Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency.
The highlighted developmental principles likely apply more generally to other developmental processes, including neurogenesis and angiogenesis.
Naturally, Drosophila is central to the book, and we have clear accounts of the role that genetics has played, and continues to play, in uncovering developmental principles.
Consistent with developmental principles, independence is achieved at lower stages in the most fundamental activities of eating, transfers, and communication.
Secondly, it will provide some examples of how developmental principles have been used to understand and potentially treat orthopedic diseases in a broader view.
The developmental principles that establish the columnar edifice of the cerebral cortex underlie its evolution and dictate its physiological operations and cognitive capacity.
In this chapter, we review strategies for directing medium spiny neuron differentiation, based on known developmental principles, and we discuss the remaining hurdles on the road to engineering such cells for therapeutic application in Huntington's disease.
Because the vascular and the nervous system show similarities at the morphological and molecular levels, and share common developmental principles coordinating their physiological growth30, these results support the important cell-autonomous role of MafB in ECs seen in vivo and in vitro.
This forward-genetic approach provides an alternative means for dissecting the molecular genetic control of neuronal population dynamics, with each genomic locus serving as a causal anchor from which we may ultimately understand the developmental principles responsible for the control of those traits.
