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Moreover, it seems likely that biomarker discovery is a more relevant priority depending on the developmental pathway of the person affected: parents of children suspected of or recently diagnosed with autism may be more likely to find value in prospective, diagnostic, or prognostic biomarkers relative to families whose children have been diagnosed for several years.
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In the case considered in this work, this is a change in shoot architecture using the material afforded by the natural variability of developmental pathways of the plant modules.
To explain their distinct cell fates, it has been proposed that asymmetric divisions generate daughter cells containing different developmental determinants [5] or that the different developmental pathways of the cells occur due to different positional cues [6].
Moreover, based on the observation of a strong correlation between nodule and lateral root number in pea, a possible overlap during early developmental pathways of the two organs has been suggested by Ferguson et al. [ 23].
Although, the functional significance of variation in substitution rates and CNE sequences found in the bat sequences currently remains unknown, this could suggest that different selective constraints have acted on the developmental pathways of the auditory systems in each of the two bat suborders.
Key traits for intimately interacting with the insect host include, among others, the capacity to colonize host tissues and the interaction with the innate immunity and the developmental pathways of the host (Ryu et al. 2008; Gross et al. 2009; Douglas et al. 2011; Shin et al. 2011; Lee et al. 2013; Login and Heddi 2013).
Our results rather suggest that the pivotal role of the UM2 in the cascade might characterise the developmental pathway of arvicolines independently of the hypermolarisation of the first lower molars.
Evidence suggests that Th17 cells share common progenitors with Treg cells and that the developmental pathways of these two subsets are reciprocally regulated [ 74].
Whilst some authors argue that the distinction between the conditions is mainly based on severity, with ODD representing a milder variant of CD, a growing body of research suggests differences in the developmental pathways of these two disorders [ 4, 7, 8, 11– 13].
The significance of this study is that it highlights the functional relevence of CD44 in defining Treg cell subsets and may explain the unique developmental pathway of CD4+Treg cells in the mouse thymus and the subtle differences between various Treg cell subsets.
The formation of embryos from somatic cells closely resembles the developmental pathway of zygotic embryos (ZEs) and hence, the molecular information generated for the SE pathway could be used to explain the dynamic molecular interactions that take place during early embryogenesis [ 1, 2].
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