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It is important that the cells to be transplanted possess, as a natural developmental option, the ability to give rise to the desired tissue, i.e. skeletal muscle in our case, at a frequency that might be clinically relevant.
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Pax5 is the decisive B lineage commitment factor that restricts the developmental options of early progenitors to the B cell pathway [25].
Finally, we determined whether TSA-treated cells acquire alternative developmental options next to DCs.
One may consider a cancerous state as one of the aberrant developmental options available to a normal cell (Kauffman 1971).
Thus, HDAC inhibition during in vitro culture slowed down DC differentiation but did not open other and/or new developmental options and cells rather retained DC differentiation potential.
In accordance with the various developmental options of the plasmodial cell we found that many P. polycephalum genes are alternatively spliced.
Also, for states facing hiring freezes or difficulties in recruiting technical staff, hiring contractors may be a cost-effective option; developmental contractor salaries were associated with a slight decrease in average costs and operational contractor wages did not significantly affect average costs.
Against this background, he proffers the democratic developmental state as the best option for Nigeria.
This system provides an excellent opportunity to address other key issues in evolutionary-developmental biology, including the evolution of morphological innovations (as are butterfly wing color patterns) and the co-option of existing developmental pathways to produce such new phenotypes.
Morphological novelties seem to arise largely through redeployment, or co-option, of conserved developmental toolkit genes (e.g., [ 6- 9]), though recent studies suggest that taxonomically restricted genes might also be important [ 10].
The size of an initiative like the NFE programme ultimately necessitated ministry leadership to reach scale, but Questscope used highly effective participatory learning methods and provided a way to experiment with innovative solutions, such as youth mentoring, strong peer support and developmental activities linked to vocational options.
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