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The GIC's application of its "developmental model" is divorced from important community resources and inconsistent with longitudinal follow-up data on outcomes of gender variant children.
Notwithstanding its success in explaining the maturation and refinement of downstream circuits and sensory maps, our understanding of the underpinnings of this developmental model is still far from complete.
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The same developmental model was proposed to explain the extreme thickness of the hard palate in Paranthropus, where palatal thickening was considered to be a simple by-product of a vertically expanded mandibular ramus [21], [25].
When one particular developmental model was examined, i.e. the transition of mouse embryonic stem cells to endodermal-like cells and then into an early pancreatic lineage in vitro, it appeared that there is a transition in the insulin promoter from full methylation to partial demethylation.
There is much more - issues of informed consent, accepting the gender variant person as client rather than having treatment driven by the parents, the archaic developmental models being used by the clinic, the lack of a planned successor to Zucker, the lack of community engagement, etc.
The most widely used avian developmental models are chicken (Gallus gallus), quail (Coturnix japonica), and zebra finch (Taeniopygia guttata).
A limitation of the aforementioned developmental BBB model was the use of adult BMECs as opposed to embryonic BMECs.
As this model is developmental further evaluation and consultation with other stakeholders is needed before it is implemented.
As a developmental mechanism, the IC Model is unusual in providing testable predictions regarding morphologies which are readily preserved in the fossil record.
The opportunity to characterize transitions to full-blown illness and developmental staging models is the first step to paradigm shifts in preventative strategies.
Another extreme model is called developmental government, which follows the success of "East Asia's Miracle".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com