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We propose an HSC developmental model in which pre-HSCs and embryonic HSCs sequentially give rise to adult types of HSCs in a stepwise manner.
We consider a developmental model in which engagement experiences produce differential outcomes.
We therefore propose a developmental model in which at the early three germ layer stage, there might be a large pool of progenitor cells within mesoderm that possess multiple lineage differentiation potentials, yet they themselves arise from proliferative growth and can be distinguished from each other by the mitotic mutations they bear.
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These mice now provide a model in which developmental effects of TDP-43 overexpression can be distinguished from degenerative effects of TDP-43 in the mature nervous system.
The age-dependent switch that we identified in the contribution of kgb-1 to stress resistance, particularly in the contribution to cadmium resistance, supports a model in which a developmental program changes the beneficial contribution of a protein to detrimental.
We are also studying the TCRβ locus, because this locus presents a model in which there is a developmental inactivation of V(D J recombination associated with the process of allelic exclusion.
Youson described naturally occurring developmental BA in lampreys [ 24], the only animal model in which the entire BA process can be traced from the beginning to the end.
This has resulted in a model in which meristem identity genes activate a developmental program that enables the shoot apical meristem to produce reproductive structures.
However, in a knockout mouse model in which the CT gene was deleted, no developmental defects were observed and procreation was normal [ 70].
Rather, our data support a model in which Macondo crude oil WAF cause specific developmental deformations that exhibit both spatial and temporal selectivity.
To study WRN's role in recombination at the organismal level, we sought to develop a model in which WRN activity may be evaluated at different developmental stages.
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