GO groups that were enriched in the lists of genes whose expression was altered by bFGF withdrawal or replacement included cancer, cell division process, cell death, apoptosis, differentiation, proliferation, developmental process, and mobilization (Fig. 6E and Table S3).
The predominant developmental timing of endogenous L1 mobilization in the brain remains unclear.
We propose that these processes represent stages of a developmental program to enable the mobilization of transposable elements (TEs), which, through quasi-random insertion, promote variation in the genome.
This is consistent with an active synthesis of cellulose and starch during these developmental stages, possibly related to the mobilization of sucrose into pathways involved in structural and storage functions.
The loss of neutral lipids (presumably triglycerides) in the fat body indicates lipid mobilization as a consequence of starvation induced by developmental arrest.
Taken together, these data demonstrate tight co-regulation of metabolic reprogramming and progression through meiosis, and hitherto unobserved partial mobilization of trehalose in response to specific arrest points in the developmental program.
These stages fall at important developmental points, such as at the beginning of seedling emergence, the end of reserve mobilization and the onset of leaf formation.
Research has so far provided strong evidence that plant cystatins regulate endogenous protein turnover during growth and developmental processes, including senescence and programmed cell death, and are further involved in accumulation and mobilization of storage proteins.
In addition, through communication, advocacy and social mobilization, the programme should target change in the general level of school preparedness or "developmental readiness‟ over the next five years.
Because transcription patterns of TEs are known to vary under different environmental conditions and/or at developmental stages, analysis of transcription profiles is the first step towards understanding what factors might induce mobilization of TEs in the host genome.
