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To fully mobilize the cell's biological potential, a new generation of tissue engineering systems is now being developed to more closely recapitulate the native developmental milieu, and mimic the physiologic mechanisms of transport and signaling.
However, there was also the possibility that the differences resulted from the economically poor living conditions characterizing their rural developmental milieu.
Conant et al. (1999) also conceded the possibility that the overall favorability of the developmental milieu (e.g., nutritional resources and health status) for children at risk from pervasive poverty might modify brain development so as to delay a natural progression in working memory towards a greater propensity for and reliance upon verbal/semantic processes.
Finally, the egg presents opportunities to directly manipulate the developmental milieu and study the consequences on adipose metabolism via in ovo injection.
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Thus, a more sensitive (and continuous) measure of the developmental androgenic milieu is desirable.
Risk factors in its multideterminant genesis reflect nutritional and developmental disadvantage and inflammatory/infectious milieu, while the major putative genetic determinants still elude detection.
Molecular interactions that link tumour progression to developmental biology provide the ideal milieu for a tumour to adapt and evade targeted therapies.
For example, removing just one molecule of the transcription factor protein, c-myb, from the cellular milieu can result in developmental defects in the B cell lineage [ 19].
Factors contributing to CKD may include low socioeconomic status with nutritional and developmental disadvantage, as well as an inflammatory/infectious milieu.
Furthermore, comparison of these pluripotent states and their necessary environmental milieu for sustenance provides indications of developmental cues (reviewed by [ 15]).
This suggests that modification of the alveolar milieu may also be possible, using soluble developmental factors that could ameliorate or reverse TGFbeta mediated fibrosis.
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