Therefore, it is unsurprising that many studies provide evidence for a causal link between the altered expression of individual miRNAs and human diseases including cancer, developmental abnormalities and malfunctions of the immune system [ 1, 4].
And although the regime seeks to appeal to sectarian divisions and invoke the threat of Iran in order to delegitimise dissent, the truth is that the discontent is found across Saudi society, fed by political repression and developmental failure, as a result of corruption, government malfunctioning, and the squandering of billions on arms.
The malfunction of the intraparietal sulcus in developmental dyscalculia participants was the basis of this prediction [ 16- 18].
Children with megalencephaly experience brain malfunction, and they typically are affected by developmental delays and seizures.
Our data supports a novel function of MID1 in directing mRNP complex-associated protein translation regulation to the cytoskeleton, malfunction of which would explain the observed developmental malformations in OS.
The suppression of developmental networks may represent a remnant of a broad malfunction of regulatory pathways leading to inaccurate boundary formation and improper structural development in the embryonic heart.
Although the biological effects of low-dose radiation less than 100 mSv have not been fully established, exposure to high-dose radiation caused by unexpected accidents related to artificial sources has many deleterious consequences in humans, including organ malfunction, malignant cancer development, genetic mutagenesis, and developmental abnormalities [ 5– 7].
Many developmental diseases have been characterized as being due to the malfunction of conserved noncoding sequences, including preaxial polydactyly [ 17], blepharophimosis syndrome [ 18], and Van Buchem disease [ 19].
Such a detailed understanding of normal developmental processes is invaluable when seeking to determine how they can malfunction.
A defect in any of the genes in the upstream part of this pathway can lead to a malfunctioning in the Calnexin/Calreticulin cycle, leading to a severe decrease of folding efficiency and to developmental defects in multicellular organisms [ 13, 14].
