Because the direct developmental links between size and shape are weak for most genotypes, size and shape can respond to such external factors differentially.
While not a focus of this manuscript, we also defined developmental links: edges connecting genes co-expressed synchronously in the course of development (exemplified at Fig. 3A; see Methods S1 for details of the calculation).
To assess the possibility that this association was caused by a direct developmental link between size and shape, we tested for allometry within genotypes by multivariate regression of shape on centroid size [28] [30].
The reviewers also found developmental links between gut microbiota and obesity.
In light of these important developmental links, we need to better understand how to characterize CFR.
There may be a cumulative developmental link, which is suggested by prior studies highlighting a significant decrease in neurogenesis observed in mast cell-deficient mice.
Previous studies have also established that SPD lies within the schizophrenia spectrum, with demonstrated genetic and developmental links with schizophrenia [ 12, 13].
Future studies that examine the developmental link between mental rotation abilities and numerical representation in young children, before and after formal education, might be able to assess the developmental trajectories of the mechanism that is proposed to underlie both skills.
Interestingly, mice with a DC-specific deletion in Notch-2 also display reduced numbers of both CD103+CD11b+ intestinal cDCs and a subset of splenic CD4+CD11b+ cDCs 25, providing additional evidence for a developmental link between these populations.
In our experiment the mature males had no opportunity for sneaking behaviour, suggesting that previous selection has generated a developmental link between the brain and the body size that is buffering relative brain size from an environmental factor, food availability.
These results provide, for the first time, a developmental link between eggs, early preimplantation embryos and ESCs, indicating that the molecular signature that characterises the ESCs identity is rooted in oogenesis.
