Summary: We present a method, LineageProgram, that uses the developmental lineage relationship of observed gene expression measurements to improve the learning of developmentally relevant cellular states and expression programs.
The developmental lineage is not much of a straight line.
The discovery of the developmental lineage and death of each cell in the nematode Caenorhabditis elegans confirmed the role of programmed cell death in development.
Belonging to the same developmental lineage as brain microglia, monocyte activation may be more directly related to psychopathology than circulating cytokines (Beumer et al. 2012; Haarman et al. 2014b).
Combinatorial strategies that engage marker intersection, anatomy and projection pattern (e.g. antero-grade and retro-grade viral vectors), and developmental lineage substantially increase the specificity of cell type targeting.
MicroRNA expression profiles also classify tumors by developmental lineage and differentiation state [10].
We observed that the percentages of RE1-containing REST, CoREST, and REST-CoREST target genes range from 25.6% to 53.0% across OL developmental lineage species.
Importantly, miRNA expression profiles appear to be more informative than mRNA expression profiles in reflecting the developmental lineage and the differentiation state of tumors [20], [22].
For example, analysis of a panel of more than 200 miRNAs from 334 chronic lymphocytic leukemia samples indicated that miRNA profiles reflected the developmental lineage and differentiation status of this neoplasm [20].
The number of DIV required for the elaboration of all differentiated progeny was determined to satisfy several essential developmental and cellular criteria, including homogeneity of the developmental lineage species examined (>95%) and the absence of alternative neural species.
Lu and collaborators [19] were the first to observe distinct patterns of miRNA expression across tumour types, and miRNA profiles reflecting the developmental lineage and the differentiation state of the tumour.
