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DOI: http://dx.doi.org/10.7554/eLife.03297.002 The developmental formation of complex multicellular organs requires the impeccable integration of cell division with differentiation.
In this case, our study reflects the positive role of Gαo in the developmental formation of glutamatergic boutons, as opposed to a role in acute fine-tuning in response to environmental factors as studied by Koon and Budnik (2012).
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Developmental bone formation occurs via two distinct pathways.
That's because the repair process mimics the steps of developmental bone formation.
This chapter briefly discusses developmental bone formation and then the current state of the art of TERM-based approaches to generate new bone by the endochondral route.
Much more than being involved in lateral inhibition, present data show that several, small-field amacrines are rather designed to transmit signals through the retinal vertical pathway; other amacrines have instructive roles for developmental map formation, but play a different task in adult life.
Moreover, my computer experiments were based on quantitative expression data that have been employed for guiding pioneering computational studies on developmental pattern formation (see Figure S1).
In the description and modeling of regulatory networks that drive developmental pattern formation, an over-simplified approach in terms of the genes involved and their interactions causes a misleading "circuitry".
Specifically, advances in microfluidics [5] [10] and biochemistry [11] [14] are beginning to open the door to direct modulation of developmental pattern formation at the spatial and temporal scale of the cell's control circuitry.
The BV display system reported here is expected to be highly useful for the analysis of cell-to-cell interaction mechanisms important in the immune system, neural system, or developmental organ formation.
Both types of bone regeneration, intramembranous and endochondral in response to fracture healing, are generally known to have parallels with developmental bone formation, and involve distinct yet interdependent healing phases consisting of biologically complex processes regulated by a very large number of transcriptional events[1] [3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com