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Considering the large synaptic changes seen in 2-month-old TASTPM mice in the CA1 region, despite the lack of plaque deposition, one possibility was that the effects seen were developmental, due to the position of transgene insertion or overexpression of the APP and/or PSEN1, independent of increasing amyloid-β levels.
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Nevertheless, this study raises the consideration that although children may not be at risk for developmental problems due to maternal education or family income, other factors may place children at risk for developmental problems.
Obviously, these normal developmental changes could also be detected in this study; however we were particularly interested in deviations from the normal developmental patterns due to the early life perturbations.
"Imagine wiping that out with an estimated 200 million kids failing to meet their full developmental potential due to malnutrition, infection, unhealthy pregnancy and birth complications.
CPH diagnosis can be difficult in developmental age, due to the frequency and duration of attacks.
However, the process has a large developmental scope due to regional heterogeneity and fluctuation characteristics.
Developmental neurotoxicity due to arsenic likely results in permanent changes in brain functions.
Enlargement or overhang of the AIIS can be developmental or due to prior avulsion or pelvic osteotomy, and can be successfully treated with arthroscopic AIIS decompression [60].
The project was designed to develop an original series of parent education materials for infants and toddlers with developmental delay due to prematurity, abnormal tone, or generalized weakness.
Philosophers of biology have shown renewed interest in developmental biology due to the potential relevance of development for understanding evolution, the theme of reductionism in genetic explanations, and via increased attention to the details of particular research programs.
Light sheet-based fluorescence microscopy became an important tool in insect developmental biology due to its high acquisition speed, low photo-bleaching rate and the high survival probability of the specimens.
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