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Reduction of Zscan4 by RNA interference showed a phenotype similar to that induced by Hmgpi knockdown: developmental deterioration at the preimplantation stages, especially cleavage pause at 2-cell stage, and failure in blastocyst outgrowth, ES-cell derivation and implantation.
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yata mutant flies showed phenotypes including developmental abnormalities, progressive deterioration of the nervous tissues, lifespan shortening, and aberrant accumulation of Sec23p.
Children in institutional care are more likely to suffer from attachment disorders, developmental delay and deterioration in brain development.
This "cell suicide" response can be triggered by normal developmental signals, disease-related deterioration or cell damage resulting from toxic exposure, low oxygen, or traumatic injury.
Core research programs include human and animal reproduction, cancer imaging and therapy, spinal cord injury and repair, cardiovascular and lung imaging and disease, bone and cartilage growth and deterioration, mammography, developmental biology, gene expression research as well as the introduction of new imaging methods.
A developmental process that is a deterioration and loss of function over time.
A serial sarcomere images from the same batch of worms acquired at different developmental stages showed progressive muscle deterioration during aging.
Continuous contamination that arises as the developmental fallout of human activities has resulted in progressive deterioration of environmental quality.
This finding has led to efforts to detect psychotic disorders early to minimise the developmental [ 5], social [ 6] and biological [ 7] deterioration that can occur after a prolonged duration of untreated psychosis (DUP).
This decline is a two-stage process that starts with a developmental phase (through maturation) and is followed by the more gradual deterioration of aging.
Developmental Psychology, 23 5), 611 626] regardless of presence or absence of cognitive deterioration [Calero, M. D., & Navarro, E. (2004). Relationship between plasticity, mild cognitive impairment and cognitive decline. Archives of Clinical Neuropsychology, 19, 653 660].
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