The congenital, but not hereditary, T-cell deficiency disease called DiGeorge syndrome arises from a developmental defect occurring in the fetus that results in the defective development of the thymus.
The cause of the disease is unknown but is thought to be a developmental defect.
Amelogenesis imperfecta (AI) is a developmental defect of dental enamel formation.
Zhou G, Ohlms L, Liberman J, Amin M. Superior semicircular canal dehiscence in a young child: implication of developmental defect.
Whereas application of IAA up to 2 mM did not result in any visible developmental defect, 5 mM IAA slightly delayed development (Supplementary Figure 7a).
Congenital absence of the uterus and vagina (CAUV) is the most extreme female reproductive tract developmental defect known.
One such condition is cryptorchidism, a developmental defect in which the testes do not descend into the scrotum (which creates a risk of developing testicular cancer).
We hypothesized that constitutive S1p2 desensitization is the underlying cause of this strong zebrafish developmental defect.
The resulting plants did not show the initial developmental defect, were resistant to abiotic stress, but were no more resistant to M. oryzae.
Importantly, the most striking phenotype in female Rpn13−/− mice was a developmental defect in the ovaries.
Heterozygous mice inheriting a deletion of either paternal or maternal origin did not have any developmental defect.
