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Patients with severe SMA show symptoms shortly after birth, suggesting a potential developmental component of SMA pathogenesis.
Severe type I-II SMA patients show symptoms during the newborn and early-infant periods, suggesting a potential developmental component of SMA pathogenesis.
A very important factor in the prevention of the developmental component of diabetes risk is the physiological state in which the parents enter pregnancy.
A very important factor in the prevention of the developmental component of diabetes risk is the physiological state in which the parents enter pregnancy – i.e. the diet, body composition and lifestyle of the mother and to a lesser extent the father.
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Recent evidence also suggests that brain development in areas controlling the developmental components of maturity may be incomplete at age 18 or beyond.
In contrast, most of the other known structural, molecular, and developmental components of the peripheral Drosophila CO2 olfactory system seem to be well-conserved across all examined lineages.
The combination of complete genomic sequence data, genetic tractability, and sophisticated analytical tools for D. melanogaster and P. fluorescens will facilitate future characterization of the cellular, molecular and developmental components of the host-microbe interactions observed in this study.
However, for most traits, it is difficult to predict genetic and developmental components of the selection process.
The mechanisms responsible for the establishment of nucleolar dominance are poorly understood but once established there is a developmental component to the maintenance of the silenced state.
There is a lack of animal models of adult-onset SMA, and the post-developmental components of SMA pathogenesis remain elusive.
The syringes present in this series are established by midgestation and do not consist of a dilation of the central canal: many appear to have a prominent developmental component with a failure of complete neural tube closure, hypoplasia of dorsal structures, and the irregular establishment of axonal tracts in the walls of the syrinx separating the lumen of the syrinx from the central canal.
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