Sentence examples for developmental candidates from inspiring English sources

Substantial costs are incurred by the late-stage failure of developmental candidates.

Market potential, competition among companies, dry pipeline of developmental candidates of various companies have hastened the drug discovery and development process.

These efforts culminated with the identification of a developmental candidate (5a), which displayed desirable PK/PD relationships, significant efficacy in the xenograft models and attractive ADME profiles.

Although we have identified "reliable" SNPs in only a subset of our UniGenes (and not necessarily those most interesting from the point of view of development), we now have gene sequence tags for many developmental candidate genes in which we can develop markers and determine the relative position on a linkage map for the 28 chromosomes of B. anynana.

To address this shortcoming, we have taken the approach of exploring the role of candidate developmental orchestrators specifically, proteins whose expression patterns mirror key developmental time-lines, and are also likely to play important cellular functions likely pivotal for neuronal development.

It will also provide experimental testing of candidate developmental disease genes suggested from clinical studies.

The idea that COPD could be associated with inappropriate growth or structural defects in small airways makes HHIP an attractive candidate developmental gene.

We also examined the association of our candidate developmental genes with infant birth weight, the outcome of fetal growth, which is one important aspect of fetal development.

As a matter of fact, Hammoud et al. demonstrated the presence in infertile men of randomly distributed histone retention genome-wide, with alteration of the methylation status of candidate developmental promoters and imprinted loci [ 111].

To clarify the genetic mechanisms that contributed to the evolution of the cephalopod camera eye, we applied comprehensive transcriptomic analysis and conducted developmental validation of candidate genes involved in coleoid cephalopod eye evolution.

This analysis suggested that misregulation of the ESRRG gene that mapped close to the chromosome 1q41 breakpoint was a plausible candidate developmental genetic mechanism for the kidney malformation in this case on the basis of striking site-specific expression in the 14.5 dpc embryonic mouse kidney.